Abstract: The spirit of historical initiative is the spiritual character of the CPC to firm historical confidence,grasp the historical trend and master the historical initiative.It comes from the inherent requirements of Marxist historical materialism,rooted in the wisdom of fine traditional Chinese culture and the spiritual pedigree with the great spirit of Party building.The spirit of historical initiative runs through the centenary practice of the CPC,demonstrating a stronger spiritual strength in the new era.On the new journey of the new era,we must constantly open up a new realm of adapting Marxism to the times,always put the people first,and adhere to the philosophy of people-centered development,constantly deepen self-revolution,advance the great project of Party building,and carry forward the historical initiative in a deep understanding of the mission and tasks of the CPC in the new era and new journey.It is of great significance to grasp the theoretical generation,centennial practice and promotion path of the historical initiative spirit of the CPC.